abstract：BACKGROUND AND PURPOSE:People with multiple sclerosis (MS) have to face important decisions with regard to their medical treatment. The aim of this study was to evaluate whether a targeted cognitive training reduces framing effects and thus improves medical judgments. METHODS:This was a randomized, double-blind, cross...

journal_title：European journal of neurology

authors： Zamarian L,Delazer M,Ehling R,Pertl MT,Bsteh G,Wenter J,Glatzl S,Brenneis C,Benke T,Berger T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Few recent data are available concerning idiopathic optic neuritis (ON). We aimed to describe a large cohort of patients with idiopathic ON. We compared this cohort with patients with ON related to myelin oligodendrocyte glycoprotein (MOG) or ON related to aquaporin-4 (AQP4) antibodies. METHODS:...

journal_title：European journal of neurology

authors： Deschamps R,Gueguen A,Lecler A,Lecouturier K,Lamirel C,Bensa C,Marignier R,Vignal C,Gout O

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Diagnosis of pharyngeal dysphagia caused by myasthenia gravis (MG) based on clinical examination alone is often challenging. Flexible endoscopic evaluation of swallowing (FEES) combined with Tensilon (edrophonium) application, referred to as the FEES-Tensilon test, was developed to improve diagno...

journal_title：European journal of neurology

authors： Im S,Suntrup-Krueger S,Colbow S,Sauer S,Claus I,Meuth SG,Dziewas R,Warnecke T

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The deleterious effect of hyperthermia on intracerebral hemorrhage (ICH) has been studied. However, the results are not conclusive and new studies are needed to elucidate clinical factors that influence the poor outcome. The aim of this study was to identify the clinical factors (including ICH et...

journal_title：European journal of neurology

authors： Iglesias-Rey R,Rodríguez-Yáñez M,Arias S,Santamaría M,Rodríguez-Castro E,López-Dequidt I,Hervella P,Sobrino T,Campos F,Castillo J

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Headache has been associated with various lifestyle and psychosocial factors, one of which is smoking. The aim of the present study was to investigate whether the association between smoking intensity and headache is likely to be causal. METHOD:A total of 58 316 participants from the Nord-Trønde...

journal_title：European journal of neurology

authors： Johnsen MB,Winsvold BS,Børte S,Vie GÅ,Pedersen LM,Storheim K,Skorpen F,Hagen K,Bjørngaard JH,Åsvold BO,Zwart JA

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Blood pressure (BP) levels in acute intracerebral hemorrhage (ICH) and mortality have not been thoroughly studied in the young. METHODS:The relationship between BP and mortality was assessed in consecutive patients with first-ever, non-traumatic acute ICH at ≤50 years of age, enrolled in the Hel...

journal_title：European journal of neurology

authors： Mustanoja S,Putaala J,Koivunen RJ,Surakka I,Tatlisumak T

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The National Institute for Health and Care Excellence (NICE) in the UK recommends the use of OnabotulinumtoxinA (BoNTA, Botox® ) in the management of chronic migraine (CM) following specific guidelines within the National Health Service. In view of the lack of data on the efficacy of this therapy...

journal_title：European journal of neurology

authors： Andreou AP,Trimboli M,Al-Kaisy A,Murphy M,Palmisani S,Fenech C,Smith T,Lambru G

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuromelanin of the brainstem, which is considered a marker of neurodegeneration in Parkinson's disease (PD), can be detected by T1-weighted neuromelanin-sensitive magnetic resonance imaging (NM-MRI). Our aim was to investigate the NM-MRI features of de novo PD and to determine whether these feat...

journal_title：European journal of neurology

authors： Wang J,Li Y,Huang Z,Wan W,Zhang Y,Wang C,Cheng X,Ye F,Liu K,Fei G,Zeng M,Jin L

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Critical illness polyneuropathy and myopathy (CIP/CIM) is being increasingly recognized as a significant clinical problem in critically ill children especially if they have spent long periods in the intensive care unit. So the aim was to determine the frequency of CIP/CIM amongst mechanically ven...

journal_title：European journal of neurology

authors： Thabet Mahmoud A,Tawfik MAM,Abd El Naby SA,Abo El Fotoh WMM,Saleh NY,Abd El Hady NMS

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Conversion disorder (CD), or functional neurological disorder, is manifested as a neurological disturbance that is not macroscopically visible on clinical structural neuroimaging and is instead ascribed to underlying psychological stress. Known for many years in neuropsychiatry, a comprehensive e...

journal_title：European journal of neurology

authors： Monsa R,Peer M,Arzy S

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ataxia-telangiectasia (A-T) is a rare neurodegenerative disease, due to A-T mutated (ATM) gene mutations, which typically presents with signs of progressive neurological dysfunction, cerebellar ataxia and uncoordinated movements. A-T severely affects patients' quality of life. Successful treatmen...

journal_title：European journal of neurology

authors： Cirillo E,Del Giudice E,Micheli R,Cappellari AM,Soresina A,Dellepiane RM,Pietrogrande MC,Dell'Era L,Specchia F,Pession A,Plebani A,Pignata C

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Detection of occult atrial fibrillation (AF) is crucial for optimal secondary prevention in stroke patients. The AF detection rate was determined by implantable cardiac monitor (ICM) and compared to the prediction rate of the probability of incident AF by software based analysis of a continuously...

journal_title：European journal of neurology

authors： Reinke F,Bettin M,Ross LS,Kochhäuser S,Kleffner I,Ritter M,Minnerup J,Dechering D,Eckardt L,Dittrich R

更新日期：2018-04-01 00:00:00

abstract：:Since the 1970s, intravenous (IV) phenytoin (PHT) has traditionally been used as second-stage treatment for convulsive status epilepticus (SE) after failure of benzodiazepines. The aim of this review was to critically assess the evidence supporting the use of IV PHT as treatment of convulsive SE in patients of any age...

journal_title：European journal of neurology

authors： Brigo F,Bragazzi NL,Lattanzi S,Nardone R,Trinka E

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Embolic strokes of undetermined source (ESUS) are a recent entity, not yet thoroughly investigated in young stroke patients. The clinical characteristics and long-term risks of vascular events and all-cause mortality between young-onset ESUS and other aetiological subgroups were compared. METHOD...

journal_title：European journal of neurology

authors： Martinez-Majander N,Aarnio K,Pirinen J,Lumikari T,Nieminen T,Lehto M,Sinisalo J,Kaste M,Tatlisumak T,Putaala J

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Calculation of the cerebrospinal fluid:serum glucose (CSF:SGlu ) ratio is part of the routine cerebrospinal fluid (CSF) work-up. Reference values have been defined for lumbar CSF, but are lacking for ventricular CSF. The objective of this study was to investigate whether the CSF:SGlu ratio is sim...

journal_title：European journal of neurology

authors： Hegen H,Walde J,Auer M,Deisenhammer F

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:CACNA1S encodes Cav 1.1, a voltage sensor for muscle excitation-contraction coupling, which activates the ryanodine receptor 1 (RYR1) leading to calcium release from the sarcoplasmic reticulum. CACNA1S mutations cause hypokalemic periodic paralysis, malignant hyperthermia and congenital myopathy....

journal_title：European journal of neurology

authors： Anandan C,Cipriani MA,Laughlin RS,Niu Z,Milone M

更新日期：2018-02-01 00:00:00

abstract：:There are about 25.7 million stroke survivors worldwide. Ischaemic stroke remains the most common type of stroke. Numerous modifiable risk factors have been identified, including behaviors such as cigarette smoking and sedentary lifestyle and treatable medical comorbidities such as hypertension, hyperlipidemia and atr...

journal_title：European journal of neurology

authors： Meschia JF,Brott T

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disorder with high morbidity and mortality. Minocycline is a matrix metalloproteinase-9 (MMP-9) inhibitor that may attenuate secondary mechanisms of injury in ICH. The feasibility and safety of minocycline in ICH patients were evalua...

journal_title：European journal of neurology

authors： Chang JJ,Kim-Tenser M,Emanuel BA,Jones GM,Chapple K,Alikhani A,Sanossian N,Mack WJ,Tsivgoulis G,Alexandrov AV,Pourmotabbed T

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Rapid eye movement sleep behaviour disorder (RBD) is related to striatal dopamine depletion. This study was performed to confirm whether clinically probable RBD (cpRBD) in patients with Parkinson's disease (PD) is associated with a specific pattern of striatal dopamine depletion. METHODS:A prosp...

journal_title：European journal of neurology

authors： Chung SJ,Lee Y,Lee JJ,Lee PH,Sohn YH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Current guidelines on cerebral venous thrombosis (CVT) diagnosis and management were issued by the European Federation of Neurological Societies in 2010. We aimed to update the previous European Federation of Neurological Societies guidelines using a clearer and evidence-based methodology. METHO...

journal_title：European journal of neurology

authors： Ferro JM,Bousser MG,Canhão P,Coutinho JM,Crassard I,Dentali F,di Minno M,Maino A,Martinelli I,Masuhr F,Aguiar de Sousa D,Stam J,European Stroke Organization.

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To compare the frequency of intrathecal immunoglobulin (Ig) synthesis in patients with symptomatic epilepsy and epilepsy of unknown etiology ('cryptogenic'). METHODS:Patients with epileptic (n = 301) and non-epileptic (n = 10) seizures were retrospectively screened for autochthonous intrathecal ...

journal_title：European journal of neurology

authors： Fauser S,Soellner C,Bien CG,Tumani H

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Porphyrias are a group of inherited metabolic disorders resulting from a specific deficiency along the pathway of haem biosynthesis. A clinical classification distinguishes acute from non-acute porphyrias considering the occurrence of life-threatening neurovisceral attacks, presenting with abdomi...

journal_title：European journal of neurology

authors： Olivier P,Van Melkebeke D,Honoré PJ,Defreyne L,Hemelsoet D

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A Consensus document on palliative care and neurology has made recommendations on the care of people with chronic and progressive neurological disease. This study aimed to investigate whether these recommendations are understood by, acceptable to and used in practice by neurologists in Belgium. ...

journal_title：European journal of neurology

authors： Vanopdenbosch LJ,Maes E,Oliver DJ

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although cerebrovascular disorders are the main cause of epilepsia partialis continua (EPC) in adulthood, the frequency of EPC after stroke is unknown. The aim was to prospectively ascertain its frequency 1 year after an ischaemic stroke. METHODS:This was a prospective study of consecutive acute...

journal_title：European journal of neurology

authors： Bentes C,Franco AC,Peralta AR,Viana P,Martins H,Morgado C,Casimiro C,Fonseca C,Geraldes R,Canhão P,Pinho E Melo T,Paiva T,Ferro JM

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Myasthenia gravis (MG) is an autoimmune disease caused by antibody mediated impairment in the neuromuscular junction. Seronegative MG (SNMG) without antibodies against acetylcholine receptor (AChR) and muscle-specific kinase (MuSK) by routine assays accounts for about 20% of all MG patients. MET...

journal_title：European journal of neurology

authors： Hong Y,Zisimopoulou P,Trakas N,Karagiorgou K,Stergiou C,Skeie GO,Hao HJ,Gao X,Owe JF,Zhang X,Yue YX,Romi F,Wang Q,Li HF,Gilhus NE,Tzartos SJ

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although there is growing and convincing evidence that socially deprived patients are at higher risk of stroke and worse outcomes, it remains controversial whether or not they suffer more severe stroke. This study aimed to evaluate the influence of social deprivation on initial clinical severity ...

journal_title：European journal of neurology

authors： Béjot Y,Guilloteau A,Joux J,Lannuzel A,Mimeau E,Mislin-Tritsch C,Fournel I,Bonithon-Kopp C,INDIA Study Group.

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:X-linked dystonia-parkinsonism (XDP) is an inherited neurodegenerative adult-onset movement disorder associated with striatal atrophy. As the dopaminergic system has not yet been systemically studied in this basal ganglia model disease, it is unclear whether nigrostriatal dysfunction contributes ...

journal_title：European journal of neurology

authors： Brüggemann N,Rosales RL,Waugh JL,Blood AJ,Domingo A,Heldmann M,Jamora RD,Münchau A,Münte TF,Lee LV,Buchmann I,Klein C

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The incidence, underlying physiopathology, features and association with lesion topography of visual hallucinations in acute stroke have scarcely been investigated. METHODS:Patients with a diagnosis of acute stroke (ischaemic or haemorrhagic) in any vascular territory, admitted within 24 h after...

journal_title：European journal of neurology

authors： Morenas-Rodríguez E,Camps-Renom P,Pérez-Cordón A,Horta-Barba A,Simón-Talero M,Cortés-Vicente E,Guisado-Alonso D,Vilaplana E,García-Sánchez C,Gironell A,Roig C,Delgado-Mederos R,Martí-Fàbregas J

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Improved biomarkers are needed to facilitate clinical decision-making and as surrogate endpoints in clinical trials in multiple sclerosis (MS). We assessed whether neurodegenerative and neuroinflammatory markers in cerebrospinal fluid (CSF) at initial sampling could predict disease activity durin...

journal_title：European journal of neurology

authors： Håkansson I,Tisell A,Cassel P,Blennow K,Zetterberg H,Lundberg P,Dahle C,Vrethem M,Ernerudh J

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Portugal has been identified as one of the countries with a high prevalence of LRRK2-G2019S, considered to be the most frequent known cause of familial and sporadic Parkinson's disease (PD). The aim of this study was to evaluate the prevalence of PD in Portugal using a door-to-door methodology. ...

journal_title：European journal of neurology

authors： Ferreira JJ,Gonçalves N,Valadas A,Januário C,Silva MR,Nogueira L,Vieira JLM,Lima AB

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence for effective treatment options for orthostatic hypotension (OH) in Parkinson's disease (PD) is scarce. Elevation of cholinergic tone with pyridostigmine bromide has been reported as a way to improve blood pressure (bp) regulation in neurogenic hypotension without causing supine hyperten...

journal_title：European journal of neurology

authors： Schreglmann SR,Büchele F,Sommerauer M,Epprecht L,Kägi G,Hägele-Link S,Götze O,Zimmerli L,Waldvogel D,Baumann CR

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Charcot-Marie-Tooth (CMT) 1C due to mutations in LITAF/SIMPLE is a rare subtype amongst the autosomal dominant demyelinating forms of CMT. Our objective was to report the clinical and electrophysiological characteristics of 18 CMT1C patients and compare them to 20 patients with PMP22 mutations: 1...

journal_title：European journal of neurology

authors： Guimarães-Costa R,Iancu Ferfoglia R,Leonard-Louis S,Ziegler F,Magy L,Fournier E,Dubourg O,Bouche P,Maisonobe T,Lacour A,Moerman A,Latour P,Stojkovic T

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebrospinal fluid (CSF) removal improves clinical symptoms of many patients with idiopathic normal-pressure hydrocephalus (iNPH). The aim of this study was to investigate the correlation of changes in the optic nerve sheath diameter (ONSD) with patient responses to CSF removal. METHODS:Transor...

journal_title：European journal of neurology

authors： Ertl M,Aigner R,Krost M,Karnasová Z,Müller K,Naumann M,Schlachetzki F

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clinically isolated syndrome (CIS) is a first demyelinating event of the central nervous system and can be a single event. After CIS, a chronic disease course with ongoing inflammation and relapses might occur, resulting in a diagnosis of multiple sclerosis (MS). As yet, there has been no prospec...

journal_title：European journal of neurology

authors： van der Vuurst de Vries RM,van Pelt ED,Mescheriakova JY,Wong YY,Ketelslegers IA,Siepman TA,Catsman CE,Neuteboom RF,Hintzen RQ

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis abnormalities in multiple sclerosis (MS) suggest their role in its pathogenesis. Interferon β (IFN-β) efficacy could be mediated also by an increase of IGF-1 levels. A 2-year longitudinal study was performed to estimate the prevalence ...

journal_title：European journal of neurology

authors： Lanzillo R,Di Somma C,Quarantelli M,Carotenuto A,Pivonello C,Moccia M,Cianflone A,Marsili A,Puorro G,Saccà F,Russo CV,De Luca Picione C,Ausiello F,Colao A,Brescia Morra V

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain atrophy is related to clinical deterioration in multiple sclerosis (MS) but its association with intrathecal markers of inflammation or neurodegeneration is unclear. Our aim was to investigate whether cerebrospinal fluid (CSF) markers of inflammation or neurodegeneration are associated with...

journal_title：European journal of neurology

authors： Mellergård J,Tisell A,Blystad I,Grönqvist A,Blennow K,Olsson B,Dahle C,Vrethem M,Lundberg P,Ernerudh J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The severity of Wilson's disease (WD) is linked to free copper accumulating in the liver and brain. Exchangeable copper (CuEXC) is a new technique to determine plasmatic copper and is useful in the diagnosis of WD. It is hypothesized that it may also enable a good evaluation of extra-hepatic invo...

journal_title：European journal of neurology

authors： Poujois A,Trocello JM,Djebrani-Oussedik N,Poupon J,Collet C,Girardot-Tinant N,Sobesky R,Habès D,Debray D,Vanlemmens C,Fluchère F,Ory-Magne F,Labreuche J,Preda C,Woimant F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Approximately 9000 people in the UK are affected by Huntington's disease (HD). People with HD require ongoing health and social care support. There is a knowledge gap about costs of health and social care use associated with HD in the UK. This paper estimates the economic cost in the UK. METHODS...

journal_title：European journal of neurology

authors： Jones C,Busse M,Quinn L,Dawes H,Drew C,Kelson M,Hood K,Rosser A,Edwards RT

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chronic syphilitic infection may lead to dementia. It is in general paresis (GP), which is the major late form of neurosyphilis, that cognitive impairment frequently occurs. The association between lipid metabolism and GP is unclear. METHODS:In this study, serum lipids were studied in 188 GP pat...

journal_title：European journal of neurology

authors： Jiang Y,Zhang YF,Liu M,Ma LL,Peng FH,Huang QL,Ma XM,Chen XH

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The clinical predictors of health-related quality of life (HRQoL) in multiple sclerosis (MS) have mainly been studied in patients with long-standing disease. The objective of this study was to investigate the longitudinal association among HRQoL and clinical characteristics in early MS. METHODS:...

journal_title：European journal of neurology

authors： Nourbakhsh B,Julian L,Waubant E

更新日期：2016-09-01 00:00:00